【佳學(xué)基因檢測】阿片類藥物成癮、遺傳易感性和藥物治療：綜述

神經(jīng)病基因檢測有用嗎分析

分析精神病分子診斷與基因分析了解《Int J Mol Sci》在.?2019 Sep 2;20(17):4294.發(fā)表了一篇題目為《阿片類藥物成癮、遺傳易感性和藥物治療：綜述》腫瘤靶向藥物治療基因檢測臨床研究文章。該研究由Shao-Cheng Wang, Yuan-Chuan Chen, Chun-Hung Lee, Ching-Ming Cheng等完成。促進(jìn)了腫瘤的正確治療與個(gè)性化用藥的發(fā)展，進(jìn)一步強(qiáng)調(diào)了基因信息檢測與分析的重要性。

神經(jīng)疾病遺傳阻斷及正確治療臨床研究內(nèi)容關(guān)鍵詞：

精神科心理科疾病用藥指導(dǎo)基因檢測臨床應(yīng)用結(jié)果

阿片類藥物成癮是一種以反復(fù)和緩解為特征的慢性復(fù)雜疾病。在過去的十年中，美國的阿片類藥物流行或阿片類藥物危機(jī)已經(jīng)提高了公眾的認(rèn)識(shí)。美沙酮、丁丙諾啡和納洛酮已證明它們在治療成癮者方面的有效性，它們各自對(duì)不同的阿片受體有不同的作用。經(jīng)典和分子遺傳學(xué)研究提供了有價(jià)值的信息，并揭示了阿片類藥物成癮易感性個(gè)體差異的可能機(jī)制?；谌蚪M關(guān)聯(lián)研究 (GWAS) 結(jié)果的多基因風(fēng)險(xiǎn)評(píng)分可能是評(píng)估整個(gè)基因組中表型和遺傳標(biāo)記之間關(guān)聯(lián)的有前途的工具。一種新的基因編輯方法，即成簇的、規(guī)則間隔的短回文重復(fù)序列 (CRISPR)，已廣泛用于基礎(chǔ)研究，并可能應(yīng)用于精神疾病等人類治療；目前正在研究許多基于 CRISPR 的成癮應(yīng)用，其中一些在動(dòng)物研究中取得了成功。在本文中，我們總結(jié)了阿片類藥物成癮的生物學(xué)機(jī)制和藥物治療，并回顧了有關(guān)阿片類藥物成癮的遺傳學(xué)、預(yù)測阿片類藥物成癮風(fēng)險(xiǎn)的有希望的方法以及一種新的基因編輯方法的文章。需要進(jìn)一步研究基于個(gè)體脆弱性的醫(yī)學(xué)治療方法。 GWAS；藥物治療;丁丙諾啡；美沙酮；納洛酮；阿片類藥物成癮；阿片類藥物依賴；阿片受體；多基因風(fēng)險(xiǎn)評(píng)分。

神經(jīng)及精神疾病及其并發(fā)征、合并征國際數(shù)據(jù)庫描述：

Opioid addiction is a chronic and complex disease characterized by relapse and remission. In the past decade, the opioid epidemic or opioid crisis in the United States has raised public awareness. Methadone, buprenorphine, and naloxone have proven their effectiveness in treating addicted individuals, and each of them has different effects on different opioid receptors. Classic and molecular genetic research has provided valuable information and revealed the possible mechanism of individual differences in vulnerability for opioid addiction. The polygenic risk score based on the results of a genome-wide association study (GWAS) may be a promising tool to evaluate the association between phenotypes and genetic markers across the entire genome. A novel gene editing approach, clustered, regularly-interspaced short palindromic repeats (CRISPR), has been widely used in basic research and potentially applied to human therapeutics such as mental illness; many applications against addiction based on CRISPR are currently under research, and some are successful in animal studies. In this article, we summarized the biological mechanisms of opioid addiction and medical treatments, and we reviewed articles about the genetics of opioid addiction, the promising approach to predict the risk of opioid addiction, and a novel gene editing approach. Further research on medical treatments based on individual vulnerability is needed.Keywords:?CRISPR; GWAS; Medical treatment; buprenorphine; methadone; naloxone; opioid addiction; opioid dependence; opioid receptors; polygenic risk score.