【佳學基因檢測】遺傳學和基因組學在臨床精神病學中的作用

精神病基因檢測哪家醫(yī)院賊好解析

閱讀精神病的正確化治療及靶向藥物選擇發(fā)現(xiàn)《Dialogues Clin Neurosci》在.?2018 Sep;20(3):169-177.發(fā)表了一篇題目為《遺傳學和基因組學在臨床精神病學中的作用》腫瘤靶向藥物治療基因檢測臨床研究文章。該研究由Margret R Hoehe, Deborah J Morris-Rosendahl等完成。促進了腫瘤的正確治療與個性化用藥的發(fā)展，進一步強調了基因信息檢測與分析的重要性。

遺傳力、發(fā)病原因及正確治療臨床研究內容關鍵詞：

神經科用藥指導基因檢測臨床應用結果

許多疾病的遺傳學和基因組學取得的巨大成功為正確醫(yī)學的進步奠定了基礎。因此，與神經精神疾病以及治療結果相關的基因變異的檢測已經引起了人們越來越多的期望，即這些發(fā)現(xiàn)可以很快轉化為臨床，以改善診斷、疾病風險的預測和個體對藥物治療的反應。在本文中，我們將介紹尋找與精神疾病有關的基因，并總結目前在主要精神疾病中的發(fā)現(xiàn)。我們將回顧編碼藥物代謝酶和特定藥物靶標的基因中的遺傳變異，這些變異被發(fā)現(xiàn)與可變的藥物反應和嚴重的副作用有關。我們將評估這些發(fā)現(xiàn)的臨床可翻譯性，目前是否有基因檢測的任何作用，并在這種情況下，為臨床醫(yī)生提供有價值的信息來源，以便在這個快速發(fā)展的精神遺傳學領域尋求指導和建議。關鍵詞：基因檢測;遺傳學；基因組學；藥物基因組學；精神障礙。

神經及精神疾病及其并發(fā)征、合并征國際數(shù)據庫描述：

The enormous successes in the genetics and genomics of many diseases have provided the basis for the advancement of precision medicine. Thus, the detection of genetic variants associated with neuropsychiatric disorders, as well as treatment outcome, has raised growing expectations that these findings could soon be translated into the clinic to improve diagnosis, the prediction of disease risk and individual response to drug therapy. In this article, we will provide an introduction to the search for genes involved in psychiatric illness and summarize the present findings in major psychiatric disorders. We will review the genetic variants in genes encoding drug metabolizing enzymes and specific drug targets which were found to be associated with variable drug response and severe side effects. We will evaluate the clinical translatability of these findings, whether there is currently any role for genetic testing and in this context, make valuable sources of information available to the clinician seeking guidance and advice in this rapidly developing field of psychiatric genetics.Keywords:?genetic testing; genetics; genomics; pharmacogenomics; psychiatric disorder.