【佳學基因檢測】外泌體微小RNA介導的腫瘤微環(huán)境中胰腺癌細胞與癌癥相關成纖維細胞之間的影響

腫瘤基因檢測哪家機構賊好導讀

根據影響腫瘤風險及靶向藥物治療效果的因素高峰論壇，《Int J Mol Sci》在. 2022 Aug 23;23(17):9512.發(fā)表了一篇題目為《外泌體微小RNA介導的腫瘤微環(huán)境中胰腺癌細胞與癌癥相關成纖維細胞之間的串擾》腫瘤靶向藥物治療基因檢測臨床研究文章。該研究由Xiangyu Chu, Yinmo Yang, Xiaodong Tian 等完成。促進了腫瘤的正確治療與個性化用藥的發(fā)展，進一步強調了基因信息檢測與分析的重要性。

腫瘤靶向藥物及正確治療臨床研究內容關鍵詞：

數據中心,癌癥相關成纖維細胞,外泌體 miRNA,腫瘤微環(huán)境

腫瘤靶向治療基因檢測臨床應用結果

胰腺導管腺癌（PDAC）是惡性程度賊高的消化道腫瘤之一，具有早期診斷率低、侵襲性強、轉移早等特點。 胰腺導管腺癌中豐富的基質細胞、致密的細胞外基質和血液供應不足限制了化療藥物的滲透，導致目前的治療方案療效不佳。癌癥相關成纖維細胞 (CAF) 是腫瘤微環(huán)境中的主要基質細胞。腫瘤細胞可以分泌外泌體促進活化CAFs的產生，同時癌癥相關成纖維細胞分泌的外泌體有助于促進腫瘤進展。外泌體中miRNAs的異常表達參與了腫瘤細胞與癌癥相關成纖維細胞的相互作用，這為外泌體miRNAs在胰腺導管腺癌診斷和治療中的應用提供了可能。本文綜述了腫瘤微環(huán)境中胰腺導管腺癌細胞與CAFs串擾中外泌體miRNA的作用機制，以期加深對TME調控的認識，并為設計針對人胰腺導管腺癌中外泌體miRNA的診斷和治療靶點提供依據。關鍵詞：PDAC ;癌癥相關成纖維細胞；外泌體 miRNA；腫瘤微環(huán)境。

腫瘤發(fā)生與反復轉移國際數據庫描述：

Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant digestive tumors, characterized by a low rate of early diagnosis, strong invasiveness, and early metastasis. The abundant stromal cells, dense extracellular matrix, and lack of blood supply in PDAC limit the penetration of chemotherapeutic drugs, resulting in poor efficacy of the current treatment regimens. Cancer-associated fibroblasts (CAFs) are the major stromal cells in the tumor microenvironment. Tumor cells can secrete exosomes to promote the generation of activated CAFs, meanwhile exosomes secreted by CAFs help promote tumor progression. The aberrant expression of miRNAs in exosomes is involved in the interaction between tumor cells and CAFs, which provides the possibility for the application of exosomal miRNAs in the diagnosis and treatment of PDAC. The current article reviews the mechanism of exosomal miRNAs in the crosstalk between PDAC cells and CAFs in the tumor microenvironment, in order to improve the understanding of TME regulation and provide evidence for designing diagnostic and therapeutic targets against exosome miRNA in human PDAC.Keywords: PDAC; cancer-associated fibroblasts; exosomal miRNAs; tumor microenvironment.