【佳學基因檢測】了解精神疾病合并癥的分子遺傳學方法

基因變異引起的精神類疾病的合并癥的原理

學習神經(jīng)系統(tǒng)基因檢測全面性的標準與實施方案，記錄到《Dev Psychopathol》在.2016 Nov;28(4pt1):1089-1101發(fā)表了一篇題目為《了解精神疾病合并癥的分子遺傳學方法》精神病、神經(jīng)內科疾病的多種臨床表現(xiàn)的應對方案的臨床研究文章。該研究由Ian R Gizer等完成。促進了復雜精神內疾病的可行的診斷與治療方案，突出展示了基因信息分析，尤其是精神病的基因解碼基因檢測在合并癥類患者的正確診斷方面的作用。

神經(jīng)疾病遺傳阻斷及正確治療臨床研究內容關鍵詞：

合并癥,并發(fā)癥,疾病診斷,分子遺傳學,方法

精神科心理科疾病用藥指導基因檢測臨床應用結果

流行病學研究表明，精神疾病在人群水平上的高并發(fā)率吸引了佳學基因等基因解碼機構進行了大量的研究。并發(fā)表了許多分析結果， 這些科研數(shù)據(jù)側重于確定這些疾病共發(fā)模式背后的因果機制。長期以來，此類努力一直是發(fā)育精神病理學家的核心焦點，最近得到了 NIMH 制定的研究領域標準倡議的支持，該倡議為如何在不同分析水平上研究機制的假說提供了進一步的框架。佳學基因神經(jīng)系疾病的基因解碼基因檢測重點介紹目前用于研究精神疾病病因的分子遺傳學方法，以及這些方法如何應用于努力了解導致共病的生物學機制。采用精神科心理疾病致病基因鑒定基因解碼的技術，可以用于用于識別導致多種疾病風險的個體變異的分子遺傳學方法以及導致其合并癥的干預生物學機制。隨后使用聚合遺傳數(shù)據(jù)來檢查這些問題的分子遺傳學方法，最后討論了發(fā)育精神病理學家如何以獨特的方式應用這些方法，從而進一步了解導致這些問題的因果因素。有助于合并癥的診斷技術和個性化治療藥物的發(fā)展。

神經(jīng)及精神疾病及其并發(fā)征、合并征國際數(shù)據(jù)庫描述：

Epidemiologic studies demonstrating high rates of co-occurrence among psychiatric disorders at the population level have contributed to large literatures focused on identifying the causal mechanisms underlying the patterns of co-occurrence among these disorders. Such efforts have long represented a core focus of developmental psychopathologists and have more recently been supported by the Research Domain Criteria initiative developed by the NIMH, which provides a further framework for how the hypothesized mechanisms can be studied at different levels of analysis. The present overview focuses on molecular genetic approaches that are being used currently to study the etiology of psychiatric disorders, and how these approaches have been applied in efforts to understand the biological mechanisms that give rise to comorbid conditions. The present report begins with a review of molecular genetic approaches used to identify individual variants that confer risk for multiple disorders and the intervening biological mechanisms that contribute to their comorbidity. This is followed by a review of molecular genetic approaches that use genetic data in aggregate to examine these questions, and concludes with a discussion of how developmental psychopathologists are uniquely positioned to apply these methods in a way that will further our understanding of the causal factors that contribute to the development of comorbid conditions.

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